منابع مشابه
Mechanisms of resistance to cabazitaxel.
We studied mechanisms of resistance to the novel taxane cabazitaxel in established cellular models of taxane resistance. We also developed cabazitaxel-resistant variants from MCF-7 breast cancer cells by stepwise selection in drug alone (MCF-7/CTAX) or drug plus the transport inhibitor PSC-833 (MCF-7/CTAX-P). Among multidrug-resistant (MDR) variants, cabazitaxel was relatively less cross-resist...
متن کاملresistance mechanisms of anopheles stephensi (diptera: culicidae) to temephos
background : anopheles stephensi is a sub-tropical species and has been considered as one of the most important vector of human malaria throughout the middle east and south asian region including the malarious areas of southern iran. current reports confirmed an. stephensi resistance to temephos in oman and india. however, there is no comprehensive research on mechanisms of temephos resistance ...
متن کاملCabazitaxel (Jevtana)
440 P&T® • August 2012 • Vol. 37 No. 8 ABSTRACT Objective: This article presents current clinical evidence supporting the use of cabazitaxel (Jevtana) in men with metastatic castration-resistant prostate cancer (mCRPC). Data Sources: We conducted a literature search using abstracts from MEDLINE and PubMed (from January 1966 to December 2011) and the American Society of Clinical Oncology (from J...
متن کاملMechanisms of resistance to camptothecins.
Camptothecins are broad-spectrum anticancer drugs that specifically target DNA topoisomerase I. Although the availability of camptothecins has had a significant impact on cancer therapeutics, de novo or acquired clinical resistance to camptothecins is common. Studies of camptothecin resistance using yeast and mammalian cell culture models suggest three general mechanisms of resistance: (1) redu...
متن کاملMechanisms of resistance to quinolones.
The increased use of fluoroquinolones has led to increasing resistance to these antimicrobials, with rates of resistance that vary by both organism and geographic region. Resistance to fluoroquinolones typically arises as a result of alterations in the target enzymes (DNA gyrase and topoisomerase IV) and of changes in drug entry and efflux. Mutations are selected first in the more susceptible t...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2014
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-14-0155